Hydrochlorothiazide, hctz; metoprolol moderate because the pharmacologic effects of metoprolol include depression of av nodal conduction and myocardial function, additive effects are possible when used in combination with cardiac glycosides, especially in patients with pre-existing left ventricular dysfunction.
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Merit-hf was a double-blind, placebo-controlled study of metoprolol succinate extended-release conducted in 14 countries including the us.
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