Aspirin interacts with a number of other drugs, including warfarin and methotrexate.
Methotrexate has been reported to cause embryotoxicity, fetal death, congenital anomalies, and abortion in humans and is contraindicated in pregnant women.
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Continue hydration at 125 ml m2 hour during the methotrexate infusion and for 2 days after the infusion has been completed.
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Methotrexate stops the rapidly growing embryonic and placental cells of early pregnancy from further developing.
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Methotrexate may also be given to treat akylosing spondylitis, rheumatoid arthritis, psoriasis, and crohn s disease.
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