Hepatic impairment — although the presence of hepatic impairment may be expected to reduce the clearance of olanzapine, a study of the effect of impaired liver function in subjects n 6 with clinically significant childs pugh classification a and b cirrhosis revealed little effect on the pharmacokinetics of olanzapine.
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although olanzapine did not change cinv in the acute phase, it showed significance in the delayed cinv group.
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olanzapine has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease.
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the addition of 5 mg day of oral olanzapine to standard therapy can reduce the frequency of cinv and improve qol for patients receiving highly or moderately emetogenic chemotherapy.
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serious drug interactions can occur when certain medicines are used with fluoxetine and olanzapine.
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additionally, sedative effects may contribute to the weight gain observed in the hyperphagic olanzapine-treated ad libitum rats.
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