The drug is marketed under many brand and generic names including aldocumar, anasmol, anticoag, befarin, cavamed, cicoxil, circuvit, cofarin, coumadin, coumadine, cumar, farin, foley, haemofarin, jantoven, kovar, lawarin, maforan, marevan, marfarin, marivanil, martefarin, morfarin, orfarin, panwarfin, scheme, simarc, varfarin, varfarins, varfine, waran, warcok, warf, warfareks, warfarin, warfarina, warfarine, warfarinum, warfen, warfin, warik, warin, warlin, and zyfarin.
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In patients with altered glomerular integrity or with a history of kidney disease, acute kidney injury may occur with coumadin, possibly in relation to episodes of excessive anticoagulation and hematuria see use in specific populations 8.
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pharmacodynamic mechanisms for drug interactions with coumadin are synergism impaired hemostasis, reduced clotting factor synthesis , competitive antagonism vitamin k , and alteration of the physiologic control loop for vitamin k metabolism hereditary resistance .