Ondansetron is less sedating than promethazine; it will not mask the neurological assessment.
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to ensure efficient urinary elimination of promethazine, you may want to take calcium-d-glucarate.
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for example, the electronic neutrality of promethazine probably facilitates its penetrance into the cns, while thioflavin s quaternary amine moiety imparts a positive charge which reduces its lipophilicity and thus negatively impacts its bio-distribution into the brain engkvist et al.
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